American depository receipts of European stocks were trading 0.34% lower at 139.18 on the Bank of New York Mellon Europe ADR index on Wednesday morning.
Decliners in Continental Europe were led Sequans Communications (SQNS), a French developer of chipset solutions, down 36.9%; followed by CGG (CGG), a manufacturer of geophysical equipment, at 4.8% lower; voxeljet (VJET), a German three-dimensional printer manufacturer, down 3.7%; and Banco Bilbao Vizcaya Argentaria (BBVA), a Spanish financial group, down 3.7%.
In the United Kingdom, shares of British healthcare company Akari Therapeutics (AKTX) were down 3.9%, followed by early-stage biopharmaceutical Midatech Pharma (MTP) decreased 3.2%, while oil and gas major Royal Dutch Shell (RDS.B) fell 0.6%.
Gainers in Continental Europe were led by Edap (EDAP), a French medical device maker, up 8.2%; followed TiGenix (TIG), a Belgium-based biopharmaceutical, 4.5% higher; DBV Technologies (DBVT), a French biopharmaceutical company, up 2.5%; and Natuzzi (NTZ), an Italian furniture manufacturer, 2.1% higher.
And, in the U.K., shares of London-based biopharmaceutical Motif Bio (MTFB) increased 22.9%, drug maker Avadel (AVDL) rose 4.8%, British biopharmaceutical GW (GWPH) increased 3.9%, and consultancy and engineering firm Amec Foster Wheeler (AMFW) rose 2.6%.